Liver-Screen®

In the event of a liver problem, transaminases (ALAT and/or ASAT) fromliver cells enter the bloodstream. The LIVER-Screen® rapid test detectsthese transaminases using specific immunological reagents when thelevel of activity of the two enzymes is greater than 80 IU/L according to theinternational reference method *I.F.C.C. The LIVER-Screen® rapid test usesa pair of antibodies specific for transaminases (ALAT and/or ASAT) whichproduce one or two coloured lines, below the T mark on the cassette, inthe event of an abnormal concentration of transaminases. A control linecapturing excess reagent appears below the C mark on the cassette.* International Federation of Clinical Chemistry.

In the event of liver dysfunction, a number of symptoms may appear, suchas dark urine, discoloured stools, loss of appetite, yellowish discolourationof the whites of the eyes or the skin, swelling of the abdomen, a feelingof weakness or extreme tiredness. In these cases, a LIVER-Screen® test isrecommended. The test can be carried out at any time of the day.

The results are accurate as long as the instructions for use are carefully followed. 

However, the result may be inaccurate if the LIVER-Screen® test is wet before use or if the wrong amount of blood is placed in the sample well. The plastic pipette supplied in the box can be used to ensure that the correct volume of blood is drawn. 

The LIVER-Screen® test should be considered positive when one or two red lines, corresponding to each transaminase (ALAT and ASAT), appear in addition to the blue line. Liver problems can lead to an increase in the concentration of a single transaminase.

The appearance of the blue line simply means that the test has worked correctly.

No. The result must be read within 10 minutes of adding the diluent. The result is reliable for up to 15 minutes.

If the result is positive, it means that the level of ALAT and/or ASAT transaminases in the blood is higher than normal (80 IU/L) and that you absolutely must consult your GP and show him/her the results of this test. Your doctor will then decide what further tests to carry out. Although determining ALT and ASAT levels is useful in diagnosing liver disease, it can be carried out in parallel with measuring the activity levels of other liver enzymes (alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transferase, etc.) and the concentration levels of other blood parameters such as urea, creatinine or bilirubin. Increased transaminase activity may be linked to other conditions or abnormalities (e.g. intensive sport, excess weight, etc.). Only a doctor can make a diagnosis after confirming these results with a clinical investigation and the results of additional tests.

If the result is negative, this means that the level of ALAT and/or ASATtransaminases is normal and below 80 IU/L. However, if symptoms persist,you should consult your GP.

Studies carried out on the LIVER-Screen® test show a correlation of 89.2%[84.8 – 92.7%]** with the reference method in clinical chemistry. Despite thereliability of this test, false positive or false negative results are possible.
**95% CI: 95% Confidence Interval